4 edition of Pharmacological regulation of gene expression in the CNS found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Kalpana Merchant.|
|Series||Pharmacology and toxicology, Pharmacology & toxicology (Boca Raton, Fla.)|
|LC Classifications||QP383.9 .P48 1996|
|The Physical Object|
|Pagination||209 p. :|
|Number of Pages||209|
|LC Control Number||96018410|
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. In addition to its fundamental contribution to our understanding of basic neuronal physiology, alterations in these neuroepigenetic mechanisms have been recently Cited by: Fos protein Immediate early gene Gene expression Immunohistochemistry Central nerve system (CNS) Neural excitation CNS disorders Drug actions This is a preview of subscription content, log in to check by: 2.
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external complementary process that involves increases of such components is called upregulation.. An example of downregulation is the cellular decrease in the expression of a.
An important overview and summary of ncRNAs. Organized into three sections: Non-coding RNAs: Form, Function and Diversity; Non-coding RNAs: Gene Regulation and Epigenetics; and Non-coding RNAs: Disease and Therapeutics. A major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research. 1 Gene expression is the process of converting the genetic information encoded in the DNA into actual gene products (i.e., proteins). This process involves two steps. In the first step, called transcription, the genetic information comprising one gene is copied into an .
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This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels.
Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, Author: Charles R. Gerfen, Kristen A Keefe, Heinz Steiner.
1st Edition Published on Janu by CRC Press This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated r.
This text focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is a review of experimental data on interactions between neuronal systems at systemic, cellular and molecular levels. Pharmacological regulation of gene expression in the CNS.
[Kalpana Merchant;] -- "This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. This book offers a comprehensive look into the science of gene expression and regulation.
Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by Cited by: Pharmacological regulation of gene expression was one of the top professional interests of Dr.
Costa. He promoted the idea that drugs can improve the endogenous mechanisms of synaptic plasticity by modulating gene : Italo Mocchetti. Shelton DL and Reichardt LF (): Studies on the regulation of beta-nerve growth factor gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as trophic factor for several distinct populations of neurons.
Proc Natl Acad Sci USA – CrossRef Google ScholarCited by: 2. Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders.
This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present.
The signalling pathways controlling both the evolution and development of language in the human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is the only gene Cited by: The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human.
The work has attracted nearly 2, citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression. Read "Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions ()" by Kalpana Merchant available from Rakuten Kobo.
This book focuses on dopamine-mediated regulation of gene expression within the Brand: CRC Press. Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression Ariadna Amador, 1 Yongjun Wang, 2 Subhashis Banerjee, 2 Theodore M.
extracellular stimuli. Much like a book on a shelf, genes do not exert effects by their mere presence; rather, the pages of the book, i.e., the chromatin, need to be opened ﬁrst so that the words, i.e., the genes, can be read and interpreted accordingly.
The “epigenetic” regulation of gene expression precisely refers to this process. The term. Pharmacological manipulation of gene expression is considered a promising avenue to reduce postischemic brain damage. Histone deacetylases (HDACs) play a central role in epigenetic regulation of transcription, and inhibitors of HDACs are emerging as neuroprotective by: The Abnormal Regulation of Gene Expression in Autistic Brain Tissue Amy E.
Purcell,1,2 Ok-Hee Jeon,1,2 and Jonathan Pevsner1,2,3 Autism is a pervasive developmental disorder of unknown etiology.
It is likely caused by mu-tations in one or more genes. One approach to understanding the molecular changes that occur. The Role of the CNS in the Regulation of HSCs.
Gene expression studies, cell-specific gene deletion experiments, and analysis of compound mutant mice showed that the parasympathetic nervous. involved in the repression of gene expression, is one target of VPA. The authors compare the actions of VPA to those of lithium, a compound that exhibits similar anticonvulsant and mood-stabilizing properties.
The actions of both compounds are delayed, which has been suggested to be due to changes in gene expression. Indeed, lithium is known to. Network γ exhibits a pattern of gene expression changes that is connected to pharmacological properties of the drugs.
Transcriptional activation of Cirbp is limited to mianserin, risperidone and clozapine treatment while opioids and psychostimulants seem to inhibit the expression of this gene and other network γ genes (e.g., Trove2 and Mrpl15).Cited by: Clinical Pharmacology And Biopharmaceutics Review.
Transcription Factors Potentially Involved in Regulation of Cytochrome P Gene Expression, Electrochemical Methods for the In Vitro Assessment of Drug Metabolism, Pharmacogenomic Technology for Personalized Medicine. Autocoids, Diuretics, Asthma, GI Pharmacology, Cardiovascular.
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) demonstrated that AUTS2 regulates neuronal gene expression through promoter association.
Conditional targeting of Auts2 in Cited by: